Active, Recombinant Human UBE2H

Background: UBE2H is a ubiquitin-conjugating enzyme (E2) that works with E3 ubiquitin ligases to catalyze the transfer of ubiquitin onto target proteins, directing them toward regulated turnover or functional modification. It participates in ubiquitin-dependent proteasomal degradation and has been implicated in pathways controlling protein homeostasis and cell fate decisions. UBE2H interacts with multiple RING-type E3 ligases and supports the formation of ubiquitin chains on selected substrates. Through these activities, it contributes to the regulation of cellular stress responses, apoptosis, and signaling networks. Dysregulation of UBE2H activity may disrupt normal ubiquitination dynamics, leading to altered protein stability and impaired cellular homeostasis.