Enzymes, Proteins, and In Vitro Assays for Targeted Protein Degradation

Empowering ubiquitin proteasome system research, degrader mechanism studies, and therapeutic development for PROTACs and molecular glues

Bioactive Ubiquitin Proteasome System Reagents

High-purity, functionally validated E1, E2, and E3 ligases
Ready-to-run in vitro assay kits
Built for specificity, stability, and scalability

Enzyme, Protein, and Assay Examples

CRBN
VHL
DCAF’s

KLHDC2
UBA1
Parkin

Cullin’s
BTK
Ubiquitin

TUBE’s
BRD4

Polyubiquitylation
Deubiquitylation
PROTAC Proximity

Gram-Level Bioactive Protein Expression Capacity

Up to 40 liters per production run
Tagged or untagged proteins
For structural studies, antigens, in vitro high throughput screening

Parameter Optimization to Enhance Yield

Optimize with up to 48 different concurrent expression parameters

E. coli strain, temperatures, media/media additives, etc.

Example protein production yields per production run

Ubiquitin: 4 g | α-Synuclein: 2 g
Tau 2N3R: 1 g | HSP70: 0.5 g

Design, expression optimization, and production are conducted at our Worcestor, MA facility

Deep Scientific Expertise

Connected to leading scientists in the UPS/TPD field.

Receive technical support from UPS scientists invested in your success.

Bioactivity & Purity

Each product is tested for relevant, meaningful, functional activity.

Count on UPS reagents with the highest specific activity and rigorous QC testing.

Call for Collaboration

Partner with our scientists to tailor solutions aligned with your research goals.

Get flexible, responsive support as your project needs evolve.