Human, Recombinant FKBP12, AVI-tag

Background: FKBP12 (FK506-binding protein 12) is a small, cytoplasmic immunophilin that functions as a peptidyl-prolyl isomerase, assisting in protein folding by catalyzing the cis-trans isomerization of proline residues. It plays a critical role in regulating cellular processes such as calcium signaling, immune response, and cell growth. FKBP12 is well known for its ability to bind immunosuppressive drugs like FK506 (tacrolimus) and rapamycin, forming complexes that inhibit key signaling pathways. One of its primary biological roles involves regulating the ryanodine receptor (RyR) calcium channels in the endoplasmic reticulum, impacting calcium release and muscle contraction. FKBP12 is also involved in modulating mTOR signaling through its interaction with rapamycin-bound complexes. Dysregulation or mutations of FKBP12 can be linked to various diseases, including autoimmune disorders, cardiac hypertrophy, and certain cancers, highlighting its importance in cellular regulation and potential as a therapeutic target.