Active, Recombinant Human FBXO22 / SKP1 Complex

Background: FBXO22 is a member of the F-box protein family and is the substrate recognition subunit of an SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase complex. This complex plays a crucial role in targeting specific proteins for ubiquitylation and subsequent degradation by the proteasome, thereby regulating various cellular processes. FBXO22 is involved in controlling cell cycle progression, signal transduction, and immune responses by targeting substrates such as p53, and mTOR. FBXO22-based degradation tools are still in early stages of development compared to more established ligases like VHL or CRBN, but they hold promise for expanding the toolkit of targeted protein degradation for therapeutic applications.