Contact Trilogie or Request a Consultation
Have a project in mind? Need to validate an E3 ligase or optimize protein expression?
We’re scientists first, and we’re here to help you move faster, with confidence.
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Join our expanding team!
We are seeking collaborative, relentless problem solvers who share our passion for science. Join our team!
Trilogie is an Equal Opportunity Employer.
Current Career Openings
Research Associate
We seek a motivated and highly skilled Research Associate to perform research experiments as defined by the supervisor and provide operational support to the laboratory. The ideal applicant will be a motivated individual with experience in protein purification and in vitroassay development. Learn more and apply on LinkedIn
R&D Scientist, Assay Development
The Scientist, Assay Development must have a proven track record and expertise with in vitro assay development and liquid handling automation. He/she will have extensive knowledge of the Ubiquitin Proteasome System (UPS) and familiarity with Targeted Protein Degradation (TPD) and will possess significant experience working with recombinant proteins. Learn more and apply on LinkedIn
R&D Scientist, Product Development
The R&D Scientist, Product Development must have a proven track record and expertise in protein biochemistry and protein purification and have extensive knowledge and experience in the fields of Ubiquitin Proteasome System (UPS) research and Targeted Protein Degradation (TPD) and have experience in setting up in vitro assays. Learn more and apply on LinkedIn
About Trilogie
High Specific Activity UPS Reagents: Discovery Begins with Functional Precision
Trilogie was founded to solve a critical gap in ubiquitin-proteasome system (UPS) research: the paucity of high-specific-activity, biologically validated reagents and services that reflect the true complexity of UPS biology. Whether you’re mapping E3-substrate interactions, screening DUB inhibitors, or engineering protein degraders, we believe experimental outcomes depend on functional precision, starting with the reagents themselves.
Our focus:
- Expression scouting and optimization for ligases, substrates, adaptors, and complex UPS proteins
- Mechanism-aligned assay development for ubiquitylation cascades and degrader mode-of-action studies
- Growing catalog of ready-to-use UPS tools designed to support academic and drug discovery researchers with reagents that perform reliably
Design, expression optimization, and production are conducted at our Worcestor, MA facility