Active, Recombinant Human KLHDC2 (1-360)

Background: Kelch repeat, beta-propeller structures. These proteins typically function as scaffolds or adaptors in various cellular processes, including protein-protein interactions, cytoskeletal organization, and signal transduction. KLHDC2 is the substrate recognition subunit of a CUL2-RING (CRL2) E3 ubiquitin-protein ligase in the DesCEND (destruction via C-end degrons) pathway. Targets of KLHDC2 include prematurely terminated SELENOK, SELENOS, and other proteins with a C-terminal glycine-glycine motif. KLHDC2-based degradation tools are still in early stages of development compared to more established ligases like VHL or CRBN, but they hold promise for expanding the toolkit of targeted protein degradation for therapeutic applications.