Active, Human, Recombinant UBE2D1

Background: Ubiquitin-Conjugating Enzyme E2 D1 (UBE2D1) is an E2 ubiquitin-conjugating enzyme that facilitates the transfer of ubiquitin from E1 activating enzymes to substrate proteins. This 147 amino acid protein is almost entirely UBC domain: an N-terminal α-helix for E3 docking, a four-stranded β-sheet, three α-helices and flexible catalytic loops. UBE2D1 is widely expressed in tissues, indicating its importance in multiple physiological processes. Its expression levels can be influenced by different stimuli, such as stress or hormonal changes. UBE2D1 interacts with various ubiquitin E3 ligases such as CHIP, MDM2, RNF4, SMURF2 and Parkin.