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Have a project in mind? Need to validate an E3 ligase or optimize protein expression?
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About Trilogie
High Specific Activity UPS Reagents: Discovery Begins with Functional Precision
Trilogie was founded to solve a critical gap in ubiquitin-proteasome system (UPS) research: the paucity of high-specific-activity, biologically validated reagents and services that reflect the true complexity of UPS biology. Whether you’re mapping E3-substrate interactions, screening DUB inhibitors, or engineering protein degraders, we believe experimental outcomes depend on functional precision, starting with the reagents themselves.
Our focus:
- Expression scouting and optimization for ligases, substrates, adaptors, and complex UPS proteins
- Mechanism-aligned assay development for ubiquitylation cascades and degrader mode-of-action studies
- Growing catalog of ready-to-use UPS tools designed to support academic and drug discovery researchers with reagents that perform reliably
Design, expression optimization, and production are conducted at our Worcestor, MA facility
