Active, Recombinant Human UBE2G1

Background: UBE2G1 is a ubiquitin-conjugating enzyme (E2) that collaborates with E3 ligases to transfer ubiquitin to substrate proteins, targeting them for proteasomal degradation. It functions in ER-associated degradation (ERAD), helping clear misfolded membrane and secretory proteins from the endoplasmic reticulum. UBE2G1 pairs with RBR and RING E3s, including components of Cullin-RING ligases, and supports K48-linked polyubiquitin chain elongation. It contributes to protein quality control, stress responses, and cellular proteostasis. Loss or inhibition of UBE2G1 can impair degradation of specific substrates, alter unfolded protein response signaling, and sensitize cells to proteotoxic stress.